10 Health Benefits Of Neem Leaves, How To Use, & Side Effects

The various benefits of neem leaves make it a must-have home remedy. Medical practitioners often prescribe neem leaves and their extract to relieve digestive difficulties, manage liver conditions, and possibly reduce the risk of cancer (1).

It contains active compounds like nimbin and azadirachtin, which can give you dandruff-free hair, clear skin, healthy teeth, and an ulcer-free stomach. In addition, the leaves contain several flavonoids, nimbanene, and vitamin C, which minimize harmful free radicals and toxic intermediates. A growing number of studies have been conducted on neem leaves and their effects against malaria and fever.

This article discusses the benefits of neem leaves, how to use them for maximum benefits, and any potential side effects. Take a look.

Know Your Ingredient: Neem Leaf

What Is It?
A leaf of the neem tree that is native to the Indian subcontinent and South Asia and widely known for its therapeutic effects.

What Are Its Benefits?
Helps improve heart health, control diabetes, and boost immunity.

Who Can Use It?
Generally beneficial for all.

How Often?
Daily.

Caution
Conduct a patch test for topical use. Medical supervision is advisable for long-term use.

Why Are Neem Leaves Therapeutic?

Various schools of medicine across the world, including Ayurveda, Unani, Homeopathy, and modern medicine, recognize the medicinal value of neem

. Its leaves, flowers, seeds, fruits, roots, and bark have been used for treating inflammation, infections, fever, skin diseases, and dental disorders and reducing the risk of cancer (1), (2).

About 140 (or more) compounds have been isolated from different parts of neem. Its leaves contain nimbin, nimbanene, vitamin C, and several flavonoids. They can eliminate toxic intermediates and free radicals from your body and aid in detoxification(1).

Research also suggests that these active ingredients help reduce the inflammation in your body. They downregulate the genes that produce pro-inflammatory compounds and work well as anticancer agents (1).

Neem leaves demonstrate anti-inflammatory, anti-diabetic, antiulcer, antimalarial, antifungal, antiseptic, antimicrobial, antioxidant, and anticancer properties (2).

Quick Tip

Don’t consume more than 4 to 5 leaves a day, 2 to 4 teaspoons of neem juice twice a day, or ¼ teaspoon of neem powder twice a day.

How Do Neem Leaves Benefit Your Health?

Neem leaves can help treat a variety of disorders related to the heart, skin, and liver due to their antioxidant activity.

They are effective against pathogenic bacteria, fungi, and viruses. The leaf extracts could be a popular option for managing diabetes as well.

1. Possess Antioxidant Effects

According to studies, the extracts of the neem leaf, flower, and bark have predominant antioxidant properties.

Polyphenols like azadirachtin and nimbolide are majorly responsible for this effect. They scavenge free radicals from your body and prevent them from damaging vital tissues and organs (1).

Thus, using neem leaves or their extracts can reduce the risk of atherosclerosisⁱ  Accumulation of plaque (fats and cholesterol) in and on the walls of arteries causing them to constrict and obstruct blood flow. , cancers, diabetes, cirrhosisⁱ  Chronic condition affecting the liver that is characterized by tissue thickness, inflammation, and cell degradation. , and other inflammatory ailments. Dried neem leaves also have shown to boost immunity in animal studies (1).

2. May Help Manage Diabetes And Hypoglycemia

Several animal studies confirm the anti-diabetic effect of neem leaves. In subjects dealing with diabetes, 250 mg of neem leaf extract per kg of body weight was found to lower glucose levels (1).

The leaf chemicals suppress the activity of enzymes that are involved in glucose metabolism. They control the amount of glucose released into the bloodstream, thereby preventing spikes in sugar levels (3).

Some animal studies claim that these extracts could regenerate the insulin-producing cells in the pancreas. Neem leaves also lower cholesterol (triglyceride) and creatinine levels, thus regulating blood pressure in the body. This way, they may protect the heart, pancreas, liver, and the kidneys from diabetes-induced inflammation (4), (5).

3. May Heal Acne And Skin/Face Issues

Neem leaf extracts are applied externally on boils and blisters in traditional medicine. They are often used in anti-acne products. Along with neem, holy basil, licorice, and green tea extracts were identified with the potential to inhibit acne-causing bacteria (Staphylococcus epidermis and Propionibacterium) (6). Therefore, applying neem powder benefits the skin by treating several skin conditions.

Poultices and decoctions of neem leaves are used to treat septic sores, ringworm, eczema, and maggot-infected burns and wounds. The active neem compounds can treat several fungal and bacterial skin infections, including athlete’s foot and abscesses (7).

4. May Protect Your Liver

The bioactive constituents of neem, including azadirachtin, have potent liver-protective (hepatoprotective) properties. Animal subjects show a reduction in the levels of inflammatory liver enzymes when treated with these extracts (1).

Neem leaves could prevent changes in the levels of bilirubin and proteins, which may lead to liver damage. Hence, you can use the extracts to treat liver injuries caused by drug overdose, particularly those caused by an overdose of anti-tuberculosis medication and generic paracetamol derivatives (1), (8).

5. Have Anti-inflammatory Properties

Clinical trials demonstrate anti-inflammatory effects of neem leaves at a dose of 200 mg/kg. Phytochemicalsⁱ  Chemical compounds found in plants, fruit, vegetables, legumes, whole grains, and nuts that have ample health benefits. like nimbidin suppress the functions of the immune system cells (e.g., macrophagesⁱ  Cells with specific functions that include locating and eliminating bacteria and other foreign entities. , neutrophilsⁱ  A specific kind of white blood cell that aids the body’s defense against infection. It is crucial to the immune system. ) in response to inflammation (1).

The leaves could reduce fever, pain, and swelling (edema) in study subjects. They prevent cell death in damaged tissues and induce cell death in cancer cells. Hence, neem extracts have been used in treating inflammatory diseases of the skin, heart, liver, and kidneys (9).

Trivia

People started using raw neem leaves and their extracts for medicinal purposes about 4,500 years ago.

6. May Exhibit Antimicrobial Effects

Neem bark, leaf, seed, and fruit extracts were studied for their antimicrobial properties. The leaves showed a significant effect on foodborne pathogens. Consuming them orally could kill endodontic bacteria and fungi. Aspergillus, Cladosporium, Alternaria, and related fungal species are particularly susceptible to neem leaves (1).

These leaves have also been studied for their antiviral effects. According to experimental studies, they interfere with the viral replication cycles. This causes inactivation of the virus and reduces the new virus yield in the host. Simply put, neem extracts can effectively lower the severity of a viral infection (1).

7. May Promote Dental Health

Nimbidin, azadirachtin, and nimbinin, the main active constituents of neem leaves, are responsible for their antibacterial properties. They are also present in the bark of this tree. Both of these (neem leaves and bark) are used in many kinds of toothpaste and toothpowders (1), (10).

They eliminate bacteria and fungi inhabiting the teeth and gums. The extracts, thus, can relieve gingivitis, tooth decay, mouth ulcers, dental caries, and plaque. Several neem products (twigs, oil, gel-cream, mouthwashes, etc.) have also been reported to help in managing oral cancers (10).

8. May Help Treat Malaria And Parasitic Diseases

This plant is proven to have antimalarial and antiplasmodic effects. Studies demonstrate how neem extracts could reduce the number of malarial parasites by 50%. Azadirachtin and limonoids available in these extracts eliminate Plasmodium berghei and  Plasmodium falciparum in affected individuals (1), (11).

However, a few trials claim neem to be ineffective against these parasites. Hence, there is a need for further research to prove the efficacy and safety of neem leaves as an antimalarial drug replacement (12).

9. May Aid Cancer Treatment

The extracts of seeds, leaves, flowers, and fruits of neem have shown antitumor effects against different types of cancer. Their phytochemicals inhibit cell proliferation and induce cell death in cancer cells. They also boost your immune response against the migration of tumors (13), (14).

Flavonoids, terpenoids, tannins, coumarins, proteins, and polysaccharides in neem leaves and seeds have been linked to such anticancer effects. They have antioxidant, anti-inflammatory, and cytotoxic properties. Therefore, neem is one of the most studied herbal remedies for aiding the treatment of cervical, ovarian, breast, stomach, oral, blood, prostate, and liver cancers (1), (13), (14).

Though evidence is insufficient, neem leaves are known to ease digestion. They reduce ulcers, gut inflammation, and other related issues if taken in small amounts.

10. May Help Treat Fungal Infections

The bioactive compounds in neem exhibit antifungal properties that may help treat several skin fungal infections (15). Studies suggest that neem may be effective against fungal strains such as Trichophyton (an athlete’s foot fungus that infects the nails and hair), Candida (a yeast-like fungus that causes lesions on the hands, vagina, and mouth), Trichosporon (a fungus of the intestinal tract), Epidermophyton (a fungus that infects the skin and toenails), and Geotrichum (a yeast-like fungus that infects the lungs, bronchi, and mucous membranes) (7).

As neem heals almost every organ system of our body, various kinds of neem products have been produced to date. Go through the next section to know what suits your needs.

How To Use Neem Leaves

Neem extracts are added to cosmetics and hair care and dental care products.

Neem oil, soaps, creams, shampoos, toothpaste, dental ointments, etc. are available commonly in the market. Neem oil is added to purified cosmetics like nail colors and facial creams. Using neem oil for hair helps nourish the scalp, reduce dandruff, and promote healthier, stronger hair growth. Several anti-dandruff and anti-lice products contain neem as well (16).

You can also topically apply a paste of neem leaves to your face. It may help reduce acne, blemishes, infected wounds, and blisters. But consult your healthcare provider before doing so.

You could also prepare neem tea. Simmer a few fresh neem leaves in a vessel of boiling water for 10 to 15 minutes. This beverage can be enjoyed either hot or cold and is well-known for its cleansing properties.

The remnants obtained after neem oil extraction are used to make ‘neem cakes.’  They are rich in carbohydrates, fiber, fat, and ash (16).

Scientists report the unique potential of neem cakes as fertilizers and as also natural insecticides. These compressed cakes contain abundant nitrogen, phosphorus, potassium, calcium, and magnesium. They can be used as manure for cash crops like sugarcane and vegetables (16).

Due to the presence of active limonoids, neem cakes protect the plant roots from nematodes and white ants, when plowed into the soil (16).

With such potent human and animal applications, the therapeutic importance of neem leaves is only increasing.

Kriti Saxena, a blogger, recalls using neem leaves for its various skin benefits: “I had the habit of raiding the kitchen every weekend to make my own face pack, but this one really has helped me. I would use dried neem, [and] haldi powder with some besan (i).”

However, a few studies report the downside of using these extracts. Scroll down to know more.

Is It Safe To Use Neem Leaves? What Are The Side Effects?

It is recommended not to have neem leaves or leaf extracts for a long time. Anecdotal evidence reports kidney failure in such people. Consuming neem oil is also regarded as unsafe/toxic for adults and children (7).

Nevertheless, various animal studies and clinical trials confirmed that neem is safe, though only at specific doses (1).

Therefore, it is best to ingest neem leaves or derivatives only under medical supervision.

If you are using neem on your skin/face, do a patch test. Apply a small amount of the neem product to a patch of skin on the forearm/leg. Wait for 24 hours to check if a reaction/allergy develops. If you see redness, rashes, swelling, or any discomfort, contact your doctor.

Also, there is insufficient information about the safety of neem products for children, pregnant, and lactating women. In these cases, it is best to refrain from ingesting or using neem without medical consent.

Infographic: 6 Ways Neem May Benefit Your Health

Neem and its components are widely utilized in Ayurveda and Asian traditional medicine. The active compounds in this herb show a promising effect as a general antiseptic and may also help manage symptoms of inflammatory and bacterial conditions. Check out the infographic below to understand how neem may help you stay healthy.

Illustration: StyleCraze Design Team

Frequently Asked Questions

Can neem leaves interact with medications?

Much anecdotal evidence suggests that neem leaves might interact with certain medications, including those for diabetes and blood pressure. However, there is limited evidence to prove these claims. Hence, it is advisable to consult your healthcare provider before use.

Can we have neem leaves daily?

Yes, neem leaves can be eaten every day. From improving blood sugar levels to dental health, they offer an array of health benefits if taken daily.

Can we boil neem leaves and drink?

Yes, neem leaves can be boiled and drunk if you cannot tolerate the bitter taste of the neem leaves while chewing them directly.

Can I take neem on an empty stomach?

Yes, neem leaves can be taken on an empty stomach. They promote gut health and skin health.

Can neem leaves be eaten raw?

Yes, neem leaves can be eaten raw. It ensures the complete absorption of nutrients.

Does neem help in weight loss?

Yes, neem can aid in effective weight loss. It revs up metabolism and breaks down the fat in the body, which helps in weight loss.

Illustration: Health Benefits Of Neem Leaves How To Use & Side Effects

Image: Stable Diffusion/StyleCraze Design Team

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Reviewer Author Editor Fact Checker

Dr.Varsha PrabalaBAMS, MD

 

Dr.Varsha is an Ayurveda doctor with 3 years of experience. She has a degree in the Indian system of medicine and MD in the field of Ayurveda Pharmacology (Dravyaguna). She has diverse work experience as a senior consultant for Government of India health projects in the northeastern and southern parts of India, under CCRAS (Central Council for research in Ayurveda sciences) and as a physician at clinics and rehabilitation centers.

Read full bio of Dr.Varsha Prabala

Swathi HandooHealth & Wellness Writer

 

Swathi holds a master’s degree in biotechnology from Osmania University and has worked in places where actual science and research happen. She has four years of experience and a Professional Certificate in Food, Nutrition & Research from Wageningen University.

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Ravi Teja TadimallaCo-Editor-in-Chief

Ravi Teja Tadimalla is a Co-Editor-in-Chief and a published author. He has been in the digital media field for over a decade. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University.

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Aparna MallampalliHealth & Wellness Writer

Aparna is a professor-turned-content writer with over 5 years of experience in life sciences. Her passion for writing and interest in the healthcare and wellness industry pushed her toward a career in content writing. She has a master’s degree in microbiology from Osmania University, Hyderabad, and a diploma in nutrition from Fab Academy.

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