Lipotropic Injections: How To Take, Dosage, & Side Effects

Lipotropic injections have gained popularity for promoting fast weight loss by burning fat. These injections contain weight loss supplements. You can use lipotropic injections along with a low-calorie, balanced diet and an effective exercise routine. Consult a licensed dermatologist as these injections contain vitamin B12, which should not be taken without a doctor-recommended weight loss plan. Read on to learn about how lipotropic injections work, their safety, if you should get them, and more. Scroll down!

What Are Lipotropic Injections?

Lipotropic injections are also called lipo shots, lipo injections, and lipotropic B12 injections. They are a series of injections administered into the body to encourage fat burning and induce a metabolism boost. Lipo injections usually contain vitamins, minerals, and amino acids. Some may also have B vitamins, such as vitamin B12 and Human Chorionic Gonadotropin (HCG). These injections are often used as a part of a weight loss regimen, including a low-calorie diet. There are a few more things you need to know about these injections, such as:

• Lipotropic injections are prescribed medications and cannot be purchased as over-the-counter items.
• Like most weight loss injections, they are not approved by the U.S. Food and Drug Administration (1).
• Though many experts suggest that lipo shots are safe, the FDA has received reports of adverse reactions from some people who used unapproved fat-dissolving injections. These reactions include permanent scarring, skin deformities, cysts, severe infections, etc (1).

So, it is highly recommended that you consult your doctor before getting them. Also, taking lipotropic injections without a weight loss plan may be dangerous. You are most likely going to find different types of lipotropic injections in different clinics.

The substance injected via a lipotropic injection is called a lipotrope. These lipotropes reduce fat production in the body. Commonly used lipotropes include (2):

•  Vitamin B12
•  Methionine
•  Inositol
•  Choline

Vitamin B12 and methionine are found in lipotropic injections, as they help maintain the body’s normal metabolic function (2). In other words, they help your body break down fats and use them properly to improve energy and overall health. However, there is no conclusive evidence that taking these nutrients can support weight loss.

Did You Know?

The technique of using injections to reduce localized fat deposits (the modern lipotropic injections) was first discovered in Italy in the 1980s (3).

Do Lipotropic Injections Work?

Lipotropic injections contain a mixture of components, primary amino acids, and some energy-boosting ingredients like vitamin B12. The amino acids in the lipo injections stimulate the liver to increase metabolism and get rid of excess fats (4). When combined with a low-calorie diet, exercise, and a healthy lifestyle, they can help you lose weight and maintain it within a normal range. Consider using a BMR calculator to optimize your weight loss plan by estimating your basal metabolic rate and tailoring your calorie intake accordingly.

Bennet Harry, a blogger, went through a similar experience when they tried to lose weight by following a low-calorie diet plan and exercising regularly along with taking liposuction injections. The blogger experienced positive results and noted, “After adding lipotropics injections to my weight loss schedule the weight came off my body with greater ease than ever before (i).”

Extensive research has been performed on lipotropic substances and their efficacy in increasing fat metabolism in the body.

A study showed that combining diet, myo-inositol, and D-chiroinositol may accelerate fat loss in women with PCOS-related obesity. However, since this is a single study, more research is required in this field (5).

Another study conducted in 2018 demonstrated that the combination of Phosphatidylcholine (PC) and Deoxycholate (DC) effectively reduced unwanted fat in the body. The cocktail showed great efficacy in treating localized fat, especially over the face and bra roll, in women between 20 to 30 years of age (6).

Another study published in the Aesthetic Surgery Journal checked the efficacy of these injections for reducing localized fat deposits. The study involved 441 patients who received up to 4 injections of a phosphatidylcholine mixture. The results showed significant reductions in fat, such as a 3.7 cm decrease in the upper belly and a 1.9 cm reduction in the thighs, with facial treatments showing particularly good results (3). No serious side effects were reported, and the fat did not return during the study period.

All these studies indicate that injection lipolysis may be an effective option for reducing small to medium fat deposits in areas resistant to diet and exercise. However, it is not a solution for large-scale weight loss or obesity and should be used alongside a healthy lifestyle.

The composition of lipotropic injections plays an important role in fat metabolism. However, we need more research in this area to figure out exactly how each substance contributes to the overall result.

There has been some research on the potential of plant-based foods as a source of lipotropes. Some plant lipotropes that have the potential to increase fat metabolism to aid weight loss include (7):

•  Choline
•  Betaine
•  Myoinositol
•  Methionine
•  Carnitine
•  Magnesium
•  Folate
•  Niacin
•  Pantothenate

An animal study published in the Critical Reviews in Food Science and Nutrition journal suggests that certain fatty acids, fibers, flavonoidsⁱ  Naturally occurring compounds in fruits and vegetables that help lower the risk of cardiovascular diseases, cancer, and cognitive conditions. , may have lipotropic effects. However, more human studies are needed to confirm these findings (7).

Despite the widespread use of lipotropic injections, there is a lack of proper research evaluating their efficacy and safety. For this reason, many doctors do not recommend these liquid lipo injections for weight loss.

How Frequently Should Lipotropic Injections Be Taken?

There is no official recommendation on how often lipotropic injections should be used for weight loss. Generally, the frequency differs from person to person and is decided by the doctor.

While some people receive a weekly injection, others might be given these injections more frequently or twice a week. If you have a vitamin B12 deficiency, your doctor might recommend vitamin B12-based lipotropic injections twice a week for an energy boost and fat metabolism. Let’s understand who can take lipotropic injections.

Who Is A Good Candidate For Lipotropic Injections?

Lipotropic injections, like any other treatment, are not recommended for everybody. Consult a doctor to understand if you are eligible for the injections. You may not be a good candidate for lipotropic injections if you:

•  Have anxiety disorder and take medications
•  Have pre-existing cardiovascular conditions
•  Have thyroid issues

Lipotropic injections work best in people who are obese or overweight but otherwise healthy and committed to lose weight and stick to the weight loss plan recommended by the doctor.

Quick Tip

Lipotropic injections may take around one month to show effective results when combined with exercise and a regular diet plan.

What Is the Dosage Of Lipotropic Injections?

The FDA does not standardize any dosage for lipotropic injections. Additionally, because there is limited research on these injections, there are only a few dosage guidelines available for reference. In a study published in the Journal of Cutaneous and Aesthetic Surgery, the maximum dose used in one sitting was 5 g (6).

The dosage depends on the total body weight. Anecdotal evidence suggests that the average dosage of a lipotropic injection usually falls anywhere between 750 to 1000 mg when you are beginning a new injection cycle.

The dosage of lipotropic injections depends on their constituents and the patient. Since lipotropic injections vary from clinic to clinic, the dosage and scheduling of these injections may vary.

Doctors recommend lipotropic injections thrice a week, but this varies based on the doctor, the clinic, and the injection constituents. Lipotropic injections often contain vitamin B12, but these two injections are different.

What Is The Difference Between B12 Shots And Lipotropic Shots?

Regular Vitamin B12 Injections

Vitamin B12 supports many vital body functions. It maintains a healthy gut and is needed for blood formation. When people are deficient in this vitamin, they are given an intramuscular injection of this vitamin B12 to improve symptoms like anemiaⁱ  A condition that results in a low number of red blood cells in the body, causing weakness, dizziness, and headaches. (8). Some experts recommend these injections for weight loss, as vitamin B12 is linked to obesity. A study published in the Medicinski Glasnik journal explores the relationship between vitamin B12 and weight. The study, conducted on 976 participants, showed that vitamin B12 levels were significantly lower in people who were obese and overweight (9). However, since no direct studies support the use of B12 injections for weight loss, more research is warranted.

Lipotropic Injections Containing Vitamin B12

Lipo shots contain lipotropes – a mixture of ingredients, such as vitamin B12, amino acids, etc. Vitamin B12 in lipotropic injections may help increase energy levels in the body (8). It is given to anyone with a specific vitamin deficiency. It may work with other lipotropes to aid fat burn and weight loss. However, there is limited scientific evidence supporting the effectiveness of these injections for weight loss.

Many clinics claim that lipotropic injections are safe because they contain ingredients that are naturally found in the body. However, these weight loss injections may have some side effects.

Lipotropic Injections: Side Effects And Precautions

According to the FDA, fat-dissolving injections that are not approved may include ingredients like phosphatidylcholine and sodium deoxycholate that are not evaluated for their safety and may lead to the following side effects (1):

• Permanent scars
• Serious infections
• Skin deformities
• Cysts
• Deep, painful knots

Like all other injections, lipotropic injections may also result in some discomfort or irritation at the injection site. They may also cause (10), (6):

• Stomach problems like diarrhea
•  Urinary issues
•  Fatigue
• Nausea
• Headache
• Body pain
• Allergic reactions (itching, hivesⁱ  A skin rash caused by allergic reactions to stress and certain foods, medications, or other substances and may lead to bumps and itching. , rashes, breathlessness)
• Tightness in the chest
• Lip swelling
• Throat discomfort
• Ulcers 
• Lightheadedness
• Pigmentation

Some lipotropic injections may contain drugs like phentermine (a drug used to suppress appetite). These injections may cause (11):

•  Diarrhea or constipation
•  Dry mouth
•  Fatigue
•  Incontinence
•  Increased heart rate
•  Anxiety
•  Insomnia
•  Feet and hand numbness
• Nausea
• Vomiting 
• Palpitations
• Elevated blood pressure

The intensity of the side effects of lipotropic injections can vary. So, closely monitor for any adverse reactions and seek medical advice if symptoms persist. If you have anxiety, cardiovascular conditions, or thyroid diseases, you must avoid lipotropic injections containing phentermine. Some individuals may experience heightened anxiety or sleep disturbances when treated with the injections containing phentermine (11).

To minimize the risk of adverse reactions, always get the injections from a registered physician. Before you begin your treatment, talk to your doctor about your medical history, any current medications, and potential allergies. This will help them check the composition of the injections to ensure you are not allergic to any ingredient. It also reduces the risk of the components interacting with any medications you may be taking. Also, discuss the benefits, risks, and expected outcomes of the procedure, and follow any pre- and post-treatment care instructions provided.

Regularly monitor your condition during the treatment period. If you experience any side effects after taking a lipotropic injection or during your weight loss treatment, get in touch with your doctor immediately.

The cost of lipotropic injections is not fixed. They may change depending on the composition and clinic. Let’s find out in detail.

The Cost Of Lipotropic Injections

The cost of lipotropic injections depends on their composition.

Usually, vitamin B12-based injections are cheaper. The cost may also vary as per the location. But, on average, you may pay anything between $20 to $50 per injection. The total cost of your lipotropic injections depends on the frequency and the duration of your treatment.

There are numerous other ways to lose weight effectively. If you do not want to take lipotropic injections, you have to work with a fitness expert and dietician for proper guidance.

Safe And Effective Weight Loss Alternatives

There are many ways to lose weight and manage obesity. According to the National Institute of Diabetes and Digestive and Kidney Diseases, adults who are overweight or obese should lose 5% to 10% of their body weight within 6 months for weight loss success and better outcomes (12).

However, people who cannot lose weight must consult with their healthcare provider for a healthy, safe, effective, and personalized weight loss plan. Good weight loss plans help you achieve a healthy weight, BMI, hip-to-waist ratio, all of which improve your overall health.

Some safe and effective weight loss alternatives include:

•  Behavioral management
•  Lifestyle counseling
•  Guidance to good sleep
•  Stress management
•  Setting slow and achievable goals
•  Constant feedback and monitoring success

Here are some lifestyle changes that are not just good habits but help you to achieve a healthy weight:

• Increase fiber and protein intake in the diet. These nutrients help promote satiety to keep you feeling fuller for longer, reducing the likelihood of overeating (13) (14).
• Drink more water, as adequate water intake is known to improve satiety and improve metabolism (15).
• Avoid processed and preserved foods and reduce your sugar consumption, as they contribute little nutritional value but add unnecessary calories to your diet. Also, limit your intake of sweetened beverages.
• Consume fresh fruits and vegetables, as they are rich in fiber. However, be mindful of portion sizes, as even healthy foods can contribute to weight gain if consumed in excess.
• Indulge in stress-relieving activities like meditation, as high stress may lead to emotional eating that may cause weight gain over time (16).
• Aim for at least 7-8 hours of sleep per night, as poor sleep can increase unhealthy food cravings (17).

Here are some other handy tips for weight management:

•  Aim for steady weight loss rather than instant results as they are not sustainable. Exercise for 30-45 minutes each day and a total of 150 minutes a week. This will help you burn calories for weight loss and also improve your overall health (18).
•  Visit your doctor and dietician regularly to monitor your progress.
•  Maintain a weight loss journal or track your progress on a mobile app.

Before your doctor recommends lipotropic injections, they might advise you to opt for these methods.

Infographic: The Pros And Cons Of Lipotropic Injections

Lipotropic injections help with quick fat loss when combined with exercise and a low-calorie diet. They mainly contain vitamin B12 along with other nutrients that promote weight loss. These injections are administered in areas that have high-fatty tissue such as the buttocks, abdomen, and thighs. But they have their fair share of cons. Scroll down to know the benefits and side effects of this injection.

Illustration: StyleCraze Design Team

Frequently Asked Questions

How long do lipotropic injections last?

While it depends on individual metabolism and the frequency of these injections, usually, they tend to last about a week or two in your system.

Do lipotropic injections suppress appetite?

Yes, anecdotal evidence suggests that lipotropic injections may help curb appetite while increasing your metabolism and aiding weight loss.

How much weight can you lose with lipotropic injections?

Between 1 to 4 pounds every week, but this depends on dosage and body type and other physical activities combined with lipotropic injections.

Are lipotropic injections permanent?

No, once you stop taking the injections your body’s metabolism returns to normal, making you susceptible to weight gain.

Are lipotropic injections effective for spot reduction of fat?

Lipotropic injections are injected in areas that have subcutaneous fat depositions and hence may aid in spot reduction of fat. However, more scientific research is required in this field.

Are Lipotropic Injections FDA-approved?

No, most lipotropic injections are not FDA-approved. Hence, it is important to consult a medical practitioner before opting for one.

Illustration: Lipotropic Injections: How To Take Dosage & Side Effects

Image: Stable Diffusion/StyleCraze Design Team

Lipotropic injections are a quick solution to losing fat. But are they safe? Check out this video to learn how they work and decide if they are right for you.

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Reviewer Author Editor Fact Checker

Dr. Priya GillMBBCH, MRCP

 

Dr. Priya Gill is a consultant dermatologist in Klang, Malaysia, with over 16 years of experience. She specializes in the management of all medical and surgical dermatology issues and has a special interest in laser therapy and phototherapy.

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Aparna MallampalliHealth & Wellness Writer

 

Aparna is a professor-turned-content writer with over 5 years of experience in life sciences. Her passion for writing and interest in the healthcare and wellness industry pushed her toward a career in content writing. She has a master’s degree in microbiology from Osmania University, Hyderabad, and a diploma in nutrition from Fab Academy.

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Ravi Teja TadimallaCo-Editor-in-Chief

Ravi Teja Tadimalla is a Co-Editor-in-Chief and a published author. He has been in the digital media field for over a decade. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University.

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Sindhu KogantiSenior Health & Wellness Writer

Sindhu Koganti is a Certified Health and Nutrition Life Coach and has over 6 years of experience in writing on health and wellness topics. She has a bachelor’s degree in biotechnology from Acharya Nagarjuna University, Guntur, and a diploma in nutrition from Fab Academy.

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